Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease
Identifieur interne : 000535 ( Main/Exploration ); précédent : 000534; suivant : 000536Sex Differences in Clinical Features of Early, Treated Parkinson’s Disease
Auteurs : Erika F. Augustine [États-Unis] ; Adriana Pérez [États-Unis] ; Rohit Dhall [États-Unis] ; Chizoba C. Umeh [États-Unis] ; Aleksandar Videnovic [États-Unis] ; Franca Cambi [États-Unis] ; Anne-Marie A. Wills [États-Unis] ; Jordan J. Elm [États-Unis] ; Richard M. Zweig [États-Unis] ; Lisa M. Shulman [États-Unis] ; Martha A. Nance [États-Unis] ; Jacquelyn Bainbridge [États-Unis] ; Oksana Suchowersky [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Creatine.
- metabolism : Parkinson Disease.
- pathology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Double-Blind Method, Female, Humans, Male, Middle Aged, Severity of Illness Index, Sex Characteristics.
Abstract
To improve our understanding of sex differences in the clinical characteristics of Parkinson’s Disease, we sought to examine differences in the clinical features and disease severity of men and women with early treated Parkinson’s Disease (PD) enrolled in a large-scale clinical trial.
Analysis was performed of baseline data from the National Institutes of Health Exploratory Trials in Parkinson’s Disease (NET-PD) Long-term Study-1, a randomized, multi-center, double-blind, placebo-controlled study of 10 grams of oral creatine/day in individuals with early, treated PD. We compared mean age at symptom onset, age at PD diagnosis, and age at randomization between men and women using t-test statistics. Sex differences in clinical features were evaluated, including: symptoms at diagnosis (motor) and symptoms at randomization (motor, non-motor, and daily functioning).
1,741 participants were enrolled (62.5% male). No differences were detected in mean age at PD onset, age at PD diagnosis, age at randomization, motor symptoms, or daily functioning between men and women. Differences in non-motor symptoms were observed, with women demonstrating better performance compared to men on SCOPA-COG (Z = 5.064, p<0.0001) and Symbol Digit Modality measures (Z = 5.221, p<0.0001).
Overall, men and women did not demonstrate differences in clinical motor features early in the course of PD. However, the differences observed in non-motor cognitive symptoms suggests further assessment of the influence of sex on non-motor symptoms in later stages of PD is warranted.
Url:
DOI: 10.1371/journal.pone.0133002
PubMed: 26171861
PubMed Central: 4501841
Affiliations:
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Augustine</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Neurology, University of Rochester Medical Center, Rochester, NY, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author><author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>The University of Texas School of Public Health, Austin, TX, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas School of Public Health, Austin, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Dhall, Rohit" sort="Dhall, Rohit" uniqKey="Dhall R" first="Rohit" last="Dhall">Rohit Dhall</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Barrow Neurological Institute, Phoenix, AZ, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea><wicri:noRegion>AZ</wicri:noRegion></affiliation></author><author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C." last="Umeh">Chizoba C. 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Augustine</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Neurology, University of Rochester Medical Center, Rochester, NY, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, NY</wicri:regionArea><wicri:noRegion>NY</wicri:noRegion></affiliation></author><author><name sortKey="Perez, Adriana" sort="Perez, Adriana" uniqKey="Perez A" first="Adriana" last="Pérez">Adriana Pérez</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>The University of Texas School of Public Health, Austin, TX, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas School of Public Health, Austin, TX</wicri:regionArea><wicri:noRegion>TX</wicri:noRegion></affiliation></author><author><name sortKey="Dhall, Rohit" sort="Dhall, Rohit" uniqKey="Dhall R" first="Rohit" last="Dhall">Rohit Dhall</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Barrow Neurological Institute, Phoenix, AZ, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea><wicri:noRegion>AZ</wicri:noRegion></affiliation></author><author><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C." last="Umeh">Chizoba C. Umeh</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Videnovic, Aleksandar" sort="Videnovic, Aleksandar" uniqKey="Videnovic A" first="Aleksandar" last="Videnovic">Aleksandar Videnovic</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, MA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, MA</wicri:regionArea><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Cambi, Franca" sort="Cambi, Franca" uniqKey="Cambi F" first="Franca" last="Cambi">Franca Cambi</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Department of Neurology, University of Kentucky, Lexington, KY, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Kentucky, Lexington, KY</wicri:regionArea><wicri:noRegion>KY</wicri:noRegion></affiliation></author><author><name sortKey="Wills, Anne Marie A" sort="Wills, Anne Marie A" uniqKey="Wills A" first="Anne-Marie A." last="Wills">Anne-Marie A. Wills</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><wicri:noRegion>MA</wicri:noRegion></affiliation></author><author><name sortKey="Elm, Jordan J" sort="Elm, Jordan J" uniqKey="Elm J" first="Jordan J." last="Elm">Jordan J. Elm</name><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC</wicri:regionArea><wicri:noRegion>SC</wicri:noRegion></affiliation></author><author><name sortKey="Zweig, Richard M" sort="Zweig, Richard M" uniqKey="Zweig R" first="Richard M." last="Zweig">Richard M. Zweig</name><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Louisiana State University Health Sciences Center, Shreveport, LA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Louisiana State University Health Sciences Center, Shreveport, LA</wicri:regionArea><wicri:noRegion>LA</wicri:noRegion></affiliation></author><author><name sortKey="Shulman, Lisa M" sort="Shulman, Lisa M" uniqKey="Shulman L" first="Lisa M." last="Shulman">Lisa M. Shulman</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Nance, Martha A" sort="Nance, Martha A" uniqKey="Nance M" first="Martha A." last="Nance">Martha A. Nance</name><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Struthers Parkinson’s Center, Minneapolis, MN, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Struthers Parkinson’s Center, Minneapolis, MN</wicri:regionArea><wicri:noRegion>MN</wicri:noRegion></affiliation></author><author><name sortKey="Bainbridge, Jacquelyn" sort="Bainbridge, Jacquelyn" uniqKey="Bainbridge J" first="Jacquelyn" last="Bainbridge">Jacquelyn Bainbridge</name><affiliation wicri:level="1"><nlm:aff id="aff012"><addr-line>University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO</wicri:regionArea><wicri:noRegion>CO</wicri:noRegion></affiliation></author><author><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>Department of Medicine, University of Alberta, Edmonton, AB, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff014"><addr-line>Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Genetics, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff015"><addr-line>Department of Pediatrics, University of Alberta, Edmonton, AB, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pediatrics, University of Alberta, Edmonton, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Creatine (metabolism)</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Severity of Illness Index</term><term>Sex Characteristics</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Creatine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Sex Characteristics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Introduction</title><p>To improve our understanding of sex differences in the clinical characteristics of Parkinson’s Disease, we sought to examine differences in the clinical features and disease severity of men and women with early treated Parkinson’s Disease (PD) enrolled in a large-scale clinical trial.</p></sec><sec id="sec002"><title>Methods</title><p>Analysis was performed of baseline data from the National Institutes of Health Exploratory Trials in Parkinson’s Disease (NET-PD) Long-term Study-1, a randomized, multi-center, double-blind, placebo-controlled study of 10 grams of oral creatine/day in individuals with early, treated PD. We compared mean age at symptom onset, age at PD diagnosis, and age at randomization between men and women using t-test statistics. Sex differences in clinical features were evaluated, including: symptoms at diagnosis (motor) and symptoms at randomization (motor, non-motor, and daily functioning).</p></sec><sec id="sec003"><title>Results</title><p>1,741 participants were enrolled (62.5% male). No differences were detected in mean age at PD onset, age at PD diagnosis, age at randomization, motor symptoms, or daily functioning between men and women. Differences in non-motor symptoms were observed, with women demonstrating better performance compared to men on SCOPA-COG (Z = 5.064, p<0.0001) and Symbol Digit Modality measures (Z = 5.221, p<0.0001).</p></sec><sec id="sec004"><title>Conclusions</title><p>Overall, men and women did not demonstrate differences in clinical motor features early in the course of PD. However, the differences observed in non-motor cognitive symptoms suggests further assessment of the influence of sex on non-motor symptoms in later stages of PD is warranted.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Irvine, K" uniqKey="Irvine K">K Irvine</name></author><author><name sortKey="Laws, Kr" uniqKey="Laws K">KR Laws</name></author><author><name sortKey="Gale, Tm" uniqKey="Gale T">TM Gale</name></author><author><name sortKey="Kondel, Tk" uniqKey="Kondel T">TK Kondel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kehoe, P" uniqKey="Kehoe P">P Kehoe</name></author><author><name sortKey="Krawczak, M" uniqKey="Krawczak M">M Krawczak</name></author><author><name sortKey="Harper, Ps" uniqKey="Harper P">PS Harper</name></author><author><name sortKey="Owen, Mj" uniqKey="Owen M">MJ Owen</name></author><author><name sortKey="Jones, Al" uniqKey="Jones A">AL Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cialone, J" uniqKey="Cialone J">J Cialone</name></author><author><name sortKey="Adams, H" uniqKey="Adams H">H Adams</name></author><author><name sortKey="Augustine, Ef" uniqKey="Augustine E">EF Augustine</name></author><author><name sortKey="Marshall, Fj" uniqKey="Marshall F">FJ Marshall</name></author><author><name sortKey="Kwon, Jm" uniqKey="Kwon J">JM Kwon</name></author><author><name sortKey="Newhouse, N" uniqKey="Newhouse N">N Newhouse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reeves, Mj" uniqKey="Reeves M">MJ Reeves</name></author><author><name sortKey="Bushnell, Cd" uniqKey="Bushnell C">CD Bushnell</name></author><author><name sortKey="Howard, G" uniqKey="Howard G">G Howard</name></author><author><name sortKey="Gargano, Jw" uniqKey="Gargano J">JW Gargano</name></author><author><name sortKey="Duncan, Pw" uniqKey="Duncan P">PW Duncan</name></author><author><name sortKey="Lynch, G" uniqKey="Lynch G">G Lynch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Towfighi, A" uniqKey="Towfighi A">A Towfighi</name></author><author><name sortKey="Zheng, L" uniqKey="Zheng L">L Zheng</name></author><author><name sortKey="Ovbiagele, B" uniqKey="Ovbiagele B">B Ovbiagele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wexler, Dj" uniqKey="Wexler D">DJ Wexler</name></author><author><name sortKey="Grant, Rw" uniqKey="Grant R">RW Grant</name></author><author><name sortKey="Meigs, Jb" uniqKey="Meigs J">JB Meigs</name></author><author><name sortKey="Nathan, Dm" uniqKey="Nathan D">DM Nathan</name></author><author><name sortKey="Cagliero, E" uniqKey="Cagliero E">E Cagliero</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Lau, Lm" uniqKey="De Lau 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Vanni</name></author><author><name sortKey="Maggi, S" uniqKey="Maggi S">S Maggi</name></author><author><name sortKey="Perissinotto, E" uniqKey="Perissinotto E">E Perissinotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Den Eeden, Sk" uniqKey="Van Den Eeden S">SK Van Den Eeden</name></author><author><name sortKey="Tanner, Cm" uniqKey="Tanner C">CM Tanner</name></author><author><name sortKey="Bernstein, Al" uniqKey="Bernstein A">AL Bernstein</name></author><author><name sortKey="Fross, Rd" uniqKey="Fross R">RD Fross</name></author><author><name sortKey="Leimpeter, A" uniqKey="Leimpeter A">A Leimpeter</name></author><author><name sortKey="Bloch, Da" uniqKey="Bloch D">DA Bloch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wooten, Gf" uniqKey="Wooten G">GF Wooten</name></author><author><name sortKey="Currie, Lj" uniqKey="Currie L">LJ Currie</name></author><author><name sortKey="Bovbjerg, Ve" uniqKey="Bovbjerg 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Marchlinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Regitz Zagrosek, V" uniqKey="Regitz Zagrosek V">V Regitz-Zagrosek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Gd" uniqKey="Anderson G">GD Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elm, Jj" uniqKey="Elm J">JJ Elm</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dorsey, Er" uniqKey="Dorsey E">ER Dorsey</name></author><author><name sortKey="Constantinescu, R" uniqKey="Constantinescu R">R Constantinescu</name></author><author><name sortKey="Thompson, Jp" uniqKey="Thompson J">JP Thompson</name></author><author><name sortKey="Biglan, Km" uniqKey="Biglan K">KM Biglan</name></author><author><name sortKey="Holloway, Rg" uniqKey="Holloway R">RG Holloway</name></author><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kowal, Sl" uniqKey="Kowal S">SL Kowal</name></author><author><name sortKey="Dall, Tm" uniqKey="Dall T">TM Dall</name></author><author><name sortKey="Chakrabarti, R" uniqKey="Chakrabarti R">R Chakrabarti</name></author><author><name sortKey="Storm, Mv" uniqKey="Storm M">MV Storm</name></author><author><name sortKey="Jain, A" uniqKey="Jain A">A Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amantea, D" uniqKey="Amantea D">D Amantea</name></author><author><name sortKey="Russo, R" uniqKey="Russo R">R Russo</name></author><author><name sortKey="Bagetta, G" uniqKey="Bagetta G">G Bagetta</name></author><author><name sortKey="Corasaniti, Mt" uniqKey="Corasaniti M">MT Corasaniti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brann, Dw" uniqKey="Brann D">DW Brann</name></author><author><name sortKey="Dhandapani, K" uniqKey="Dhandapani K">K Dhandapani</name></author><author><name sortKey="Wakade, C" uniqKey="Wakade C">C Wakade</name></author><author><name sortKey="Mahesh, Vb" uniqKey="Mahesh V">VB Mahesh</name></author><author><name sortKey="Khan, Mm" uniqKey="Khan M">MM Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourque, M" uniqKey="Bourque M">M Bourque</name></author><author><name sortKey="Dluzen, De" uniqKey="Dluzen D">DE Dluzen</name></author><author><name sortKey="Di Paolo, T" uniqKey="Di Paolo T">T Di Paolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haaxma, Ca" uniqKey="Haaxma C">CA Haaxma</name></author><author><name sortKey="Bloem, Br" uniqKey="Bloem B">BR Bloem</name></author><author><name sortKey="Borm, Gf" uniqKey="Borm G">GF Borm</name></author><author><name sortKey="Oyen, Wj" uniqKey="Oyen W">WJ Oyen</name></author><author><name sortKey="Leenders, Kl" uniqKey="Leenders K">KL Leenders</name></author><author><name sortKey="Eshuis, S" uniqKey="Eshuis S">S Eshuis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baba, Y" uniqKey="Baba Y">Y Baba</name></author><author><name sortKey="Putzke, Jd" uniqKey="Putzke J">JD Putzke</name></author><author><name sortKey="Whaley, Nr" uniqKey="Whaley N">NR Whaley</name></author><author><name sortKey="Wszolek, Zk" uniqKey="Wszolek Z">ZK Wszolek</name></author><author><name sortKey="Uitti, Rj" uniqKey="Uitti R">RJ Uitti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diamond, Sg" uniqKey="Diamond S">SG Diamond</name></author><author><name sortKey="Markham, Ch" uniqKey="Markham C">CH Markham</name></author><author><name sortKey="Hoehn, Mm" uniqKey="Hoehn M">MM Hoehn</name></author><author><name sortKey="Mcdowell, Fh" uniqKey="Mcdowell F">FH McDowell</name></author><author><name sortKey="Muenter, Md" uniqKey="Muenter M">MD Muenter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P Martinez-Martin</name></author><author><name sortKey="Falup Pecurariu, C" uniqKey="Falup Pecurariu C">C Falup Pecurariu</name></author><author><name sortKey="Odin, P" uniqKey="Odin P">P Odin</name></author><author><name sortKey="Van Hilten, Jj" uniqKey="Van Hilten J">JJ van Hilten</name></author><author><name sortKey="Antonini, A" uniqKey="Antonini A">A Antonini</name></author><author><name sortKey="Rojo Abuin, Jm" uniqKey="Rojo Abuin J">JM Rojo-Abuin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyons, Ke" uniqKey="Lyons K">KE Lyons</name></author><author><name sortKey="Hubble, Jp" uniqKey="Hubble J">JP Hubble</name></author><author><name sortKey="Troster, Ai" uniqKey="Troster A">AI Troster</name></author><author><name sortKey="Pahwa, R" uniqKey="Pahwa R">R Pahwa</name></author><author><name sortKey="Koller, 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sortKey="Stavitsky, K" uniqKey="Stavitsky K">K Stavitsky</name></author><author><name sortKey="Cronin Golomb, A" uniqKey="Cronin Golomb A">A Cronin-Golomb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimprich, A" uniqKey="Zimprich A">A Zimprich</name></author><author><name sortKey="Grabowski, M" uniqKey="Grabowski M">M Grabowski</name></author><author><name sortKey="Asmus, F" uniqKey="Asmus F">F Asmus</name></author><author><name sortKey="Naumann, M" uniqKey="Naumann M">M Naumann</name></author><author><name sortKey="Berg, D" uniqKey="Berg D">D Berg</name></author><author><name sortKey="Bertram, M" uniqKey="Bertram M">M Bertram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Hoek, Tc" uniqKey="Van Der Hoek T">TC van der Hoek</name></author><author><name sortKey="Bus, Ba" uniqKey="Bus B">BA Bus</name></author><author><name sortKey="Matui, P" uniqKey="Matui P">P Matui</name></author><author><name 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Shulman</name><name sortKey="Umeh, Chizoba C" sort="Umeh, Chizoba C" uniqKey="Umeh C" first="Chizoba C." last="Umeh">Chizoba C. Umeh</name><name sortKey="Videnovic, Aleksandar" sort="Videnovic, Aleksandar" uniqKey="Videnovic A" first="Aleksandar" last="Videnovic">Aleksandar Videnovic</name><name sortKey="Wills, Anne Marie A" sort="Wills, Anne Marie A" uniqKey="Wills A" first="Anne-Marie A." last="Wills">Anne-Marie A. Wills</name><name sortKey="Zweig, Richard M" sort="Zweig, Richard M" uniqKey="Zweig R" first="Richard M." last="Zweig">Richard M. Zweig</name></country><country name="Canada"><noRegion><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name></noRegion><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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